Methods, apparatus, systems and articles of manufacture for automatic database failover in a master-replica replication configuration are disclosed. An example node within a database system having a plurality of nodes, includes an agent to select a first database operated at one of the plurality of nodes to function as a master database in a master-replica replication configuration. The agent is to cause the selected database to be configured as the master database. The agent is to configure a first reverse proxy of the node. The first reverse proxy is to receive a query from a load balancer and forward the query to the master database based on the configuration.