Systems, methods, and instrumentalities are disclosed for active interference management. Active interference management may be provided for designated data regions and/or superzones. UAV-specific or other designated data regions (e.g., with data zones) may enable dynamic inter-cell interference management and high reliability command & control for UAVs in interference prone in environments. Data zone/region specific control channel search space may support inter-cell interference cancellation. Aggregation N levels (e.g., during EPDCCH encoding) may be dependent on an interference level of a zone. Data zone specific reference signals (DS-RS) may enable UAVs connected to neighboring cells to estimate an interference channel per zone. Interference management may be provided during semi-persistent scheduling (SPS) transmissions. Reliability of Physical Downlink Control Channel (PDCCH) may be enhanced (EPDCCH), e.g., with interference assistance signaling. Uplink interference management may operate with dedicated data region/zones. A downlink control information (DCI) format may be provided for UAVs.