- 专利标题： Methods of quantifying N2-(1-carboxyethyl)-2′-deoxy-guanosine (CEdG) and synthesis of oligonucleotides containing CEdG
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申请号： US15887857申请日： 2018-02-02
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公开(公告)号： US11179361B2公开(公告)日： 2021-11-23
- 发明人: Samuel Rahbar , Timothy W. Synold , John Termini , Gerald Wuenschell , Daniel Tamae
- 申请人： CITY OF HOPE
- 申请人地址： US CA Duarte
- 专利权人： CITY OF HOPE
- 当前专利权人： CITY OF HOPE
- 当前专利权人地址： US CA Duarte
- 代理机构： Perkins Coie LLP
- 代理商 Lara J. Dueppen; Courtney Prochnow
- 主分类号： G01N30/72
- IPC分类号： G01N30/72 ; A61P3/10 ; A61K31/195 ; G01N33/68 ; G01N30/88 ; A61N5/10 ; A61K45/06 ; G01N30/04 ; A61K31/121
摘要：
Methods of quantifying a N2-(1-carboxyethyl)-2′-deoxyguanosine (CEdG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of metabolic disorders or complications associated therewith, including diabetes, its associated complications, and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG levels before and after treatment. Measurement of CEdG levels is achieved by using liquid chromatography electrospray ionization tandem mass spectrometry.
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