公开(公告)号：US11266618B2

公开(公告)日：2022-03-08

申请号：US15859188

申请日：2017-12-29

申请人： CITY OF HOPE

发明人： Samuel Rahbar ,  Timothy W. Synold ,  John Termini ,  Daniel Tamae ,  Gerald Wuenschell

IPC分类号： A61K31/195 ,  G01N30/72 ,  G01N30/04 ,  G01N30/88 ,  A61K45/06 ,  A61N5/10

摘要： Methods of quantifying N2-carboxyethyl-2′-deoxyguanosine (CEdG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of disorders, including diabetes and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG levels before and after treatment. Measurement of CEdG levels occurs using liquid chromatography electrospray ionization tandem mass spectrometry.

公开(公告)号：US11179361B2

公开(公告)日：2021-11-23

申请号：US15887857

申请日：2018-02-02

申请人： CITY OF HOPE

发明人： Samuel Rahbar ,  Timothy W. Synold ,  John Termini ,  Gerald Wuenschell ,  Daniel Tamae

IPC分类号： G01N30/72 ,  A61P3/10 ,  A61K31/195 ,  G01N33/68 ,  G01N30/88 ,  A61N5/10 ,  A61K45/06 ,  G01N30/04 ,  A61K31/121

摘要： Methods of quantifying a N2-(1-carboxyethyl)-2′-deoxyguanosine (CEdG) levels in biological samples and comparing those levels to known normal levels can diagnose a number of metabolic disorders or complications associated therewith, including diabetes, its associated complications, and cancer. Methods can also determine whether therapies for disorders are effective by measuring CEdG levels before and after treatment. Measurement of CEdG levels is achieved by using liquid chromatography electrospray ionization tandem mass spectrometry.