Invention Grant
- Patent Title: Dimethoxyphenyl substituted indole compounds as TLR7, TLR8 or TLR9 inhibitors
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Application No.: US16321616Application Date: 2017-07-27
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Publication No.: US11180474B2Publication Date: 2021-11-23
- Inventor: Alaric J. Dyckman , Dharmpal S. Dodd , Christopher P. Mussari , Tasir S. Haque , Michael A. Poss , Louis J. Lombardo , John E. Macor , Laxman Pasunoori , Sreekantha Ratna Kumar
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agent Gary Greenblatt
- Priority: IN1026137 20160730
- International Application: PCT/US2017/044091 WO 20170727
- International Announcement: WO2018/026620 WO 20180208
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D405/14 ; C07D417/14 ; C07D451/02 ; C07D401/04 ; C07D413/14 ; A61P37/06 ; C07D409/14
Abstract:
Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R3, R4, R5, m, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
Public/Granted literature
- US20210292300A1 DIMETHOXYPHENYL SUBSTITUTED INDOLE COMPOUNDS AS TLR7, TLR8 OR TLR9 INHIBITORS Public/Granted day:2021-09-23
Information query
