公开(公告)号：US11180474B2

公开(公告)日：2021-11-23

申请号：US16321616

申请日：2017-07-27

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Christopher P. Mussari ,  Tasir S. Haque ,  Michael A. Poss ,  Louis J. Lombardo ,  John E. Macor ,  Laxman Pasunoori ,  Sreekantha Ratna Kumar

IPC: C07D401/14 ,  C07D405/14 ,  C07D417/14 ,  C07D451/02 ,  C07D401/04 ,  C07D413/14 ,  A61P37/06 ,  C07D409/14

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R3, R4, R5, m, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US20210292300A1

公开(公告)日：2021-09-23

申请号：US16321616

申请日：2017-07-27

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Christopher P. Mussari ,  Tasir S. Haque ,  Michael A. Poss ,  Louis J. Lombardo ,  John E. Macor ,  Laxman Pasunoori ,  Sreekantha Ratna Kumar

IPC: C07D401/14 ,  C07D401/04 ,  C07D405/14 ,  C07D417/14 ,  C07D451/02 ,  C07D409/14 ,  C07D413/14 ,  A61P37/06

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein R1; R3, R4, R5, m, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.