Examples described herein relate to customization of courses of action for responding to incidents in information technology (IT) environments. An incident management service executes incident response monitoring, identification and remediation across an IT environment for one or more entities that may have their own configuration of computing assets (computing environment) within the IT environment. A course of action outlines remediation actions for responding to specific types of incidents within an IT environment. A course of action is customized for implementation within a particular computing environment associated with an entity. Customization of a course of action comprises generation and implementation of instruction sets that are usable to tailor remedial actions for execution in computing environments of different entities. An instruction set provides commands/calls that are specific to computing assets associated with an entity, which are usable to execute remedial actions for a specific type of incident.