A network node includes a bus switching element, and a network adapter, an accelerator and a host, all coupled to communicate via the bus switching element. The network adapter is configured to communicate with remote nodes over a communication network. The host is configured to establish a RDMA link between the accelerator and the RDMA endpoint by creating a Queue Pair (QP) to be used by the accelerator for communication with the RDMA endpoint via the RDMA link. The accelerator is configured to exchange data, via the network adapter, between a memory of the accelerator and a memory of the RDMA endpoint.