A desalination system includes a feed pump having an inlet side and an outlet side. In addition, the system includes a first RO stage having an inlet, RO permeate outlet and RO concentrate outlet. Further, the system includes a second RO stage having an inlet, RO permeate outlet and RO concentrate outlet and an NF stage having an inlet, NF permeate outlet and an NF concentrate outlet. The system also includes a set of conduits adapted to connect: (a) the outlet side of the feed pump to the inlet of the first RO stage; (b) the concentrate outlet of the first RO stage to (i) the inlet of the second RO stage and to the inlet of the NF stage; and (c) the permeate outlet of the first RO stage, the permeate outlet of the second RO stage and the permeate outlet of the NF stage either directly or indirectly to a low salinity water injection line.