A method for mobile robotic based inspection includes delivery of inspection requirements identifying a part and one or more inspection mode types. A three-dimensional model of the part and one or more physical attributes or specifications of the aeronautical part are received. A plurality of different motion sequences for the robot inspection system are determined to evaluate a plurality of predefined points on the component using one or more sensors for the one or more inspection types. Data acquisition parameters are determined for inspection sequence to allow for collection of inspection data for one or more inspection modes. A motion sequence from the plurality of different motion sequences is selected based on one or more parameters. An optimized inspection program configured to update operating parameters of the robot inspection system to perform the selected motion sequence and capture data using the one or more sensors is generated.