![Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof](/docs/US/2021-11-30/US11186584B2/abs.jpg.600x600.jpg)
- Patent Title: Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
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Application No.: US17230288Application Date: 2021-04-14
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Publication No.: US11186584B2Publication Date: 2021-11-30
- Inventor: Ayman Allian , Jayanthy Jayanth , Mohamed-Eslam F. Mohamed , Mathew Mulhern , Fredrik Lars Nordstrom , Ahmed A. Othman , Michael J. Rozema , Lakshmi Bhagavatula , Patrick J. Marroum , Peter T. Mayer , Ahmad Y. Sheikh , Thomas B. Borchardt , Ben Klünder
- Applicant: AbbVie Inc.
- Applicant Address: US IL North Chicago
- Assignee: AbbVie Inc.
- Current Assignee: AbbVie Inc.
- Current Assignee Address: US IL North Chicago
- Agent Cristin H. Cowles; Danielle L. Herritt; Scott R. Breining
- Main IPC: C07D487/14
- IPC: C07D487/14 ; A61K9/00 ; A61K31/4985 ; A61K47/12 ; A61K47/38
![Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof](/abs-image/US/2021/11/30/US11186584B2/abs.jpg.150x150.jpg)
Abstract:
The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.
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