公开(公告)号：US11633497B2

公开(公告)日：2023-04-25

申请号：US17661450

申请日：2022-04-29

申请人： AbbVie Inc.

发明人： Andrew C. Phillips ,  Regina M. Reilly ,  George A. Doherty ,  Cheng Ji ,  Milan Bruncko ,  Erwin R. Boghaert ,  Mark Anderson

IPC分类号： A61K47/68 ,  C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  C07D491/22 ,  C07K5/068

摘要： The present disclosure provides c-Met antibody drug conjugates (ADCs), including compositions and methods of using such ADCs.

公开(公告)号：USD982156S1

公开(公告)日：2023-03-28

申请号：US29699801

申请日：2019-07-29

申请人： AbbVie Inc.

设计人： Ian Charles Cleathero ,  Carsten Petersen

公开(公告)号：US11564922B2

公开(公告)日：2023-01-31

申请号：US17732070

申请日：2022-04-28

申请人： AbbVie Inc.

发明人： Aileen L. Pangan ,  Roopal B. Thakkar ,  Steven Jungerwirth ,  Ana Paula Machado De Lacerda ,  Anne M. Robinson ,  Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Ben Klünder ,  Wen Zhou

IPC分类号： A61K31/4985 ,  A61K31/495 ,  A61P1/00 ,  A61K9/00 ,  A61K9/48

摘要： The present disclosure is directed to methods for treating Crohn's disease, and in particular, to methods for inducing clinical remission and/or endoscopic improvement of Crohn's disease, using a JAK1 inhibitor. In certain embodiments, the patient is administered an induction dose of the JAK1 inhibitor to induce clinical remission and/or endoscopic improvement of the Crohn's disease, followed by administration of at least one maintenance dose of the JAK1 inhibitor thereafter. In other embodiments, the present disclosure is directed to methods for treating ulcerative colitis using a JAK1 inhibitor.

公开(公告)号：US20230019186A1

公开(公告)日：2023-01-19

申请号：US17651187

申请日：2022-02-15

申请人： AbbVie Inc. ,  AbbVie Deutschland GmbH & Co. KG

发明人： John Hayslip ,  Leanne M. Holes ,  Sven Mensing ,  Silpa Nuthalapati

IPC分类号： A61K31/5377 ,  A61P35/00 ,  A61K31/52

摘要： The invention described herein relates to methods for treating a human subject with myelofibrosis or an MPN-related disorder, comprising administering navitoclax to the subject optionally in combination with ruxolitinib.

公开(公告)号：US20220306643A1

公开(公告)日：2022-09-29

申请号：US17827064

申请日：2022-05-27

申请人： AbbVie Inc.

发明人： Aileen L. Pangan ,  Henrique D. Teixeira ,  Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Ben Klünder

IPC分类号： C07D487/14 ,  A61K47/38 ,  A61K47/12 ,  A61K31/4985 ,  A61K9/00 ,  A61K9/20

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3Himidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20220259226A1

公开(公告)日：2022-08-18

申请号：US17660355

申请日：2022-04-22

申请人： AbbVie Inc. ,  AbbVie Deutschland GmbH & Co. KG

发明人： Wilfried Braje ,  George Doherty ,  Katja Jantos ,  Cheng Ji ,  Andrew Judd ,  Aaron Kunzer ,  Anthony Mastracchio ,  Xiaohong Song ,  Andrew Souers ,  Gerard Sullivan ,  Zhi-Fu Tao ,  Chunqiu Lai ,  Jesse Teske ,  Michael Wendt ,  Patrick Brady ,  Xilu Wang ,  Thomas Penning ,  Yujia Dai ,  Jane Gong ,  Roberto Risi ,  Yiyun Yu ,  Guidong Zhu

IPC分类号： C07D498/18 ,  A61P35/00 ,  C07D519/00 ,  C07D495/18 ,  C07D495/16 ,  A61K31/519 ,  C07D491/16 ,  C07D498/16

摘要： The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

公开(公告)号：US20220251123A1

公开(公告)日：2022-08-11

申请号：US17446807

申请日：2021-09-02

申请人： Calico Life Sciences LLC ,  AbbVie Inc.

发明人： Kathleen Ann Martin ,  Carmela Sidrauski ,  Michael J. Dart ,  Jennifer M. Frost ,  Yunsong Tong ,  Xiangdong Xu ,  Lei Shi ,  Kathleen Murauski ,  Marina Pliushchev ,  Brian S. Brown ,  Eric Voight ,  John T. Randolph

IPC分类号： C07F9/12

摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

公开(公告)号：US20220251101A1

公开(公告)日：2022-08-11

申请号：US17717486

申请日：2022-04-11

申请人： AbbVie Inc.

发明人： Ayman ALLIAN ,  Jayanthy JAYANTH ,  Mohamed-Eslam F. MOHAMED ,  Mathew MULHERN ,  Fredrik Lars NORDSTROM ,  Ahmed A. OTHMAN ,  Michael J. ROZEMA ,  Lakshmi BHAGAVATULA ,  Patrick J. MARROUM ,  Peter T. MAYER ,  Ahmad Y. SHEIKH ,  Thomas B. BORCHARDT ,  Ben KLÜNDER

IPC分类号： C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

摘要： The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and various spondyloarthritic conditions, including types of axial spondyloarthritis (axSpA)), kits, methods of synthesis, and products-by-process. In various aspects, provided are methods for treating active non-radiographic axSpA (nr-axSpA) and methods for treating active ankylosing spondylitis (AS).

公开(公告)号：US20220213092A1

公开(公告)日：2022-07-07

申请号：US17552396

申请日：2021-12-16

申请人： AbbVie Inc.

发明人： David A. DeGoey ,  Felix DeAnda, Jr. ,  Amanda W. Dombrowski ,  Igor Dubovyk ,  Stephen N. Greszler ,  Dimitri Khrakovsky ,  Chih-Hung Lee ,  James N. Newton ,  Elizabeth L. Noey ,  Akinori Okano ,  Kevin B. Sippy ,  Andrew J. Souers ,  Longcheng Wang ,  Noel S. Wilson ,  Jeffery A. Zablocki

IPC分类号： C07D471/04 ,  C07D519/00 ,  C07D487/04

摘要： The present invention provides for compounds of formula (I) wherein A, R1, R2, R4, W, m, and n have any of the values defined herein, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of CLL and/or SLL.

公开(公告)号：US11358773B2

公开(公告)日：2022-06-14

申请号：US16932181

申请日：2020-07-17

申请人： AbbVie Inc.

发明人： Lori Kim ,  Alexandra Breban-Lopez ,  Bhimaprasad Medhal ,  Dejan Bojicic ,  Guy Upchurch ,  John G. Finch ,  Lewis Sita

IPC分类号： B65D5/50 ,  B65D77/04 ,  B65D83/04 ,  A61J1/03 ,  A61J7/04 ,  B65D5/42 ,  B65D75/36 ,  B65D77/22 ,  B65D77/00

摘要： A medication packaging and dispensing system is provided. The system may include a plurality of medication booklets containing medication and a tray that is configured to retain the medication booklets. Each medication booklet may include a sequential tab assembly of pull tabs that aligns with a plurality of front cutouts and a plurality of back cutouts. This alignment configuration facilitates dispensing the medication from the medication booklet. The tray may include a riser that extends from a bottom wall of the tray at an oblique angle, and a first guide panel including a plurality of linear stops. The oblique angle may correspond to a pitch of the first guide panel. The riser and the plurality of linear stops may cooperate to maintain the medication booklets in a staggered configuration that is substantially parallel to the bottom wall of the tray. The system may further include a container for retaining the tray.