Invention Grant
- Patent Title: Radioactive phospholipid metal chelates for cancer imaging and therapy
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Application No.: US16891181Application Date: 2020-06-03
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Publication No.: US11186598B2Publication Date: 2021-11-30
- Inventor: Jamey Weichert , Anatoly Pinchuk , Reinier Hernandez
- Applicant: Wisconsin Alumni Research Foundation
- Applicant Address: US WI Madison
- Assignee: Wisconsin Alumni Research Foundation
- Current Assignee: Wisconsin Alumni Research Foundation
- Current Assignee Address: US WI Madison
- Agency: Boyle Fredrickson S.C.
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61M36/14 ; C07F9/6524 ; C07B59/00 ; G01N33/574 ; A61K51/04 ; A61N5/10 ; G01N33/60

Abstract:
Alkylphosphocholine analogs incorporating a chelating moiety that chelates a radioactive metal isotope are disclosed herein. The alkylphophocholine analogs, which can be used to treat or detect solid tumors, have the formula: R1 includes a chelating agent that is chelated to a metal atom, wherein the metal atom is a positron or single photon emitting metal isotope with a half life of greater than or equal to 4 hours, or an alpha, beta or Auger emitting metal isotope with a half life of greater than 6 hours and less than 30 days; a is 0 or 1; n is an integer from 12 to 30; m is 0 or 1; Y is —H, —OH, —COOH, —COOX, —OCOX, or —OX, wherein X is an alkyl or an arylalkyl; R2 is —N+H3, —N+H2Z, —N+HZ2, or —N+Z3, wherein each Z is independently an alkyl or an aroalkyl; and b is 1 or 2.
Public/Granted literature
- US20200291049A1 Radioactive Phospholipid Metal Chelates for Cancer Imaging and Therapy Public/Granted day:2020-09-17
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