- 专利标题： Compositions and methods for evaluating and modulating immune responses by detecting and targeting POU2AF1
-
申请号： US15966244申请日： 2018-04-30
-
公开(公告)号： US11186825B2公开(公告)日： 2021-11-30
- 发明人: Aviv Regev , Ana Carrizosa Anderson , Le Cong , Vijay K. Kuchroo , Meromit Singer , Chao Wang
- 申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc.
- 申请人地址： US MA Cambridge; US MA Cambridge; US MA Boston
- 专利权人： The Broad Institute, Inc.,Massachusetts Institute of Technology,The Brigham and Women's Hospital, Inc.
- 当前专利权人： The Broad Institute, Inc.,Massachusetts Institute of Technology,The Brigham and Women's Hospital, Inc.
- 当前专利权人地址： US MA Cambridge; US MA Cambridge; US MA Boston
- 代理机构： Johnson, Marcou, Isaacs & Nix, LLC
- 代理商 F. Brent Nix, Esq.; Michael B. Scher, Esq.
- 主分类号： C12N5/0783
- IPC分类号： C12N5/0783 ; A61K35/17 ; A61K39/00 ; C12Q1/6881 ; C12Q1/6886 ; C07K14/00 ; C07K14/47 ; G01N33/50 ; A61K45/06 ; C12N15/10 ; C12Q1/6883
摘要：
The present invention provides markers, marker signatures and molecular targets that correlate with dysfunction of immune cells and are advantageously independent of the immune cell activation status. The present markers, marker signatures and molecular targets provide for new ways to evaluate and modulate immune responses. Specifically, POU2AF1 modulation is provided for use as a marker, marker signature and molecular target. Therapeutic methods are also provided to treat a patient in need thereof who would benefit from an increased immune response.
公开/授权文献
信息查询
