Systems, methods, and computer-readable media are disclosed for automated item sortation and container handling. In one embodiment, an example method may include determining, by a controller, a first item identifier of a first item at an induction portion of a sortation system, determining an order identifier associated with the first item identifier, and determining a first container associated with the order identifier. The method may include causing a first mobile carrier unit to receive the item, and causing the first mobile carrier unit to deliver the first item to the first container.