发明授权
- 专利标题： Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR)
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申请号： US15776591申请日： 2016-11-17
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公开(公告)号： US11213586B2公开(公告)日： 2022-01-04
- 发明人: Changyu Wang , Nils Lonberg , Alan J. Korman , Mark J. Selby , Mohan Srinivasan , Karla A. Henning , Michelle Minhua Han , Guodong Chen , Richard Y. Huang , Indrani Chakraborty , Haichun Huang , Susan Chien-Szu Wong , Huiming Li , Bryan C. Barnhart , Aaron P. Yamniuk , Ming Lei , Liang Schweizer , Sandra V. Hatcher , Arvind Rajpal
- 申请人： BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址： US NJ Princeton
- 专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人： BRISTOL-MYERS SQUIBB COMPANY
- 当前专利权人地址： US NJ Princeton
- 代理机构： Nelson Mullins Riley & Scarborough LLP
- 代理商 Jane E. Remillard, Esq.; Christopher L. Frank
- 国际申请： PCT/US2016/062540 WO 20161117
- 国际公布： WO2017/087678 WO 20170526
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K39/395 ; G01N33/574 ; G01N33/68 ; A61K39/00
摘要：
Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
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