公开(公告)号：US11466092B2

公开(公告)日：2022-10-11

申请号：US16847130

申请日：2020-04-13

Applicant: Bristol-Myers Squibb Company

Inventor： Zhehong Cai ,  Indrani Chakraborty ,  Marie-Michelle Navarro Garcia ,  Thomas D. Kempe ,  Alan J. Korman ,  Alexander T. Kozhich ,  Hadia Lemar ,  Mark Maurer ,  Christina Maria Milburn ,  Michael Quigley ,  Xiang Shao ,  Mohan Srinivasan ,  Kent Thudium ,  Susan Chien-Szu Wong ,  Jochem Gokemeijer ,  Xi-Tao Wang ,  Han Chang ,  Patrick Guirnalda

IPC: A61K39/00 ,  A61K39/395 ,  G01N33/53 ,  C07K16/28 ,  C07K16/30 ,  A61P35/00 ,  G01N33/574

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

公开(公告)号：US11213586B2

公开(公告)日：2022-01-04

申请号：US15776591

申请日：2016-11-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Changyu Wang ,  Nils Lonberg ,  Alan J. Korman ,  Mark J. Selby ,  Mohan Srinivasan ,  Karla A. Henning ,  Michelle Minhua Han ,  Guodong Chen ,  Richard Y. Huang ,  Indrani Chakraborty ,  Haichun Huang ,  Susan Chien-Szu Wong ,  Huiming Li ,  Bryan C. Barnhart ,  Aaron P. Yamniuk ,  Ming Lei ,  Liang Schweizer ,  Sandra V. Hatcher ,  Arvind Rajpal

IPC: C07K16/28 ,  A61K39/395 ,  G01N33/574 ,  G01N33/68 ,  A61K39/00

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

公开(公告)号：US11408889B2

公开(公告)日：2022-08-09

申请号：US16870006

申请日：2020-05-08

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Xi-Tao Wang ,  Olufemi A. Adelakun ,  Anne C. Lewin ,  Alan J. Korman ,  Mark J. Selby ,  Changyu Wang ,  Haichun Huang ,  Karla A. Henning ,  Nils Lonberg ,  Mohan Srinivasan ,  Michelle Minhua Han ,  Guodong Chen ,  Richard Y. Huang ,  Indrani Chakraborty ,  Susan Chien-Szu Wong ,  Huiming Li

IPC: G01N33/566 ,  G01N33/574 ,  C07K16/28

Abstract: Provided herein are diagnostic antibodies that bind to glucocorticoid-induced tumor necrosis factor receptor (GITR). Such antibodies are useful for methods of detecting the expression of GITR in biological samples, for example, tumor tissue, and identifying a cancer patient likely to respond to anti-GITR immunotherapy or predicting whether a cancer patient will respond to anti-GITR immunotherapy.

公开(公告)号：US09644032B2

公开(公告)日：2017-05-09

申请号：US15166114

申请日：2016-05-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Zhehong Cai ,  Indrani Chakraborty ,  Marie-Michelle Navarro Garcia ,  Thomas D. Kempe ,  Alan J. Korman ,  Alexander T. Kozhich ,  Hadia Lemar ,  Mark Maurer ,  Christina Maria Milburn ,  Michael Quigley ,  Xiang Shao ,  Mohan Srinivasan ,  Kent Thudium ,  Susan Chien-Szu Wong ,  Jochem Gokemeijer ,  Xi-Tao Wang ,  Han Chang ,  Patrick Guirnalda

IPC: C07K16/28 ,  A61K39/395 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/2878 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3038 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/574

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

公开(公告)号：US10690674B2

公开(公告)日：2020-06-23

申请号：US15578874

申请日：2016-06-02

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Xi-Tao Wang ,  Olufemi A. Adelakun ,  Anne C. Lewin ,  Alan J. Korman ,  Mark J. Selby ,  Changyu Wang ,  Haichun Huang ,  Karla A. Henning ,  Nils Lonberg ,  Mohan Srinivasan ,  Michelle Minhua Han ,  Guodong Chen ,  Richard Y. Huang ,  Indrani Chakraborty ,  Susan Chien-Szu Wong ,  Huiming Li

IPC: G01N33/566 ,  G01N33/574 ,  C07K16/28

Abstract: Provided herein are diagnostic antibodies that bind to glucocorticoid-induced tumor necrosis factor receptor (GITR). Such antibodies are useful for methods of detecting the expression of GITR in biological samples, for example, tumor tissue, and identifying a cancer patient likely to respond to anti-GITR immunotherapy or predicting whether a cancer patient will respond to anti-GITR immunotherapy.

公开(公告)号：US10683357B2

公开(公告)日：2020-06-16

申请号：US15474731

申请日：2017-03-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Zhehong Cai ,  Indrani Chakraborty ,  Marie-Michelle Navarro Garcia ,  Thomas D. Kempe ,  Alan J. Korman ,  Alexander T. Kozhich ,  Hadia Lemar ,  Mark Maurer ,  Christina Maria Milburn ,  Michael Quigley ,  Xiang Shao ,  Mohan Srinivasan ,  Kent Thudium ,  Susan Chien-Szu Wong ,  Jochem Gokemeijer ,  Xi-Tao Wang ,  Han Chang ,  Patrick Guirnalda

IPC: C07H21/04 ,  C12P21/06 ,  C12N15/87 ,  C12N1/20 ,  C12N5/20 ,  C12N15/00 ,  C07K16/28 ,  C07K16/30 ,  A61P35/00 ,  A61K39/395 ,  G01N33/574 ,  A61K39/00

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.