- 专利标题： Human monoclonal antibodies specific for FLT3 and uses thereof
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申请号： US16471485申请日： 2017-12-21
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公开(公告)号： US11236171B2公开(公告)日： 2022-02-01
- 发明人: Dimiter S. Dimitrov , Weizao Chen , Terry J. Fry , Christopher Chien , Haiying Qin
- 申请人： The U.S.A., as represented by the Secretary, Department of Health and Human Services
- 申请人地址： US MD Bethesda
- 专利权人： The U.S.A., as represented by the Secretary, Department of Health and Human Services
- 当前专利权人： The U.S.A., as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： US MD Bethesda
- 代理机构： Klarquist Sparkman, LLP
- 国际申请： PCT/US2017/067974 WO 20171221
- 国际公布： WO2018/119279 WO 20180628
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K39/395 ; G01N33/53 ; A61K47/69 ; A61K47/68 ; A61P35/02 ; A61P35/04 ; A61P35/00 ; C07K14/725 ; C07K14/705 ; C07K16/46 ; G01N33/577
摘要：
Human monoclonal antibodies that specifically bind Fms-like tyrosine kinase 3 (FLT3) are described. Chimeric antigen receptors (CARs) and other antibody conjugates that include the FLT3-specific monoclonal antibodies are also described. Methods for the diagnosis and treatment of FLT3-associated cancer, such as acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML), are further described.
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