Invention Grant
- Patent Title: Small molecule inhibitors of lactate dehydrogenase and methods of use thereof
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Application No.: US17160868Application Date: 2021-01-28
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Publication No.: US11247971B2Publication Date: 2022-02-15
- Inventor: David J. Maloney , Alex Gregory Waterson , Ganesh Rai Bantukallu , Kyle Ryan Brimacombe , Plamen Christov , Chi V. Dang , Victor Darley-Usmar , Xin Hu , Ajit Jadhav , Somnath Jana , Kwangho Kim , Jennifer L. Kouznetsova , William J. Moore , Bryan T. Mott , Leonard M. Neckers , Anton Simeonov , Gary Allen Sulikowski , Daniel Jason Urban , Shyh Ming Yang
- Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , VANDERBILT UNIVERSITY , The UAB Research Foundation , The Trustees of the University of Pennsylvania
- Applicant Address: US MD Bethesda; US TN Nashville; US AL Birmingham; US PA Philadelphia
- Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES,VANDERBILT UNIVERSITY,The UAB Research Foundation,The Trustees of the University of Pennsylvania
- Current Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES,VANDERBILT UNIVERSITY,The UAB Research Foundation,The Trustees of the University of Pennsylvania
- Current Assignee Address: US MD Bethesda; US TN Nashville; US AL Birmingham; US PA Philadelphia
- Agency: Cantor Colburn LLP
- Main IPC: C07D231/20
- IPC: C07D231/20 ; C07D231/38 ; C07D401/04 ; C07D403/04 ; C07D403/06 ; C07D409/04 ; C07D413/04 ; C07D417/04 ; C07D417/14 ; C07D471/04 ; C07D495/04 ; C07D495/14 ; A61K31/415 ; A61K31/4155 ; A61K31/4178 ; A61K31/422 ; A61K31/427 ; A61K31/437 ; A61K31/454 ; A61K31/496 ; A61K31/501 ; A61K31/506 ; A61K31/519 ; A61K31/5355 ; A61K31/4439 ; A61K45/06
Abstract:
Provided is a compound of formula (I), in which Ar1, R1, U, V, W, X, and p are as described herein. Also provided are methods of using a compound of formula (I), including a method of treating cancer, a method of treating a patient with cancer cells resistant to an anti-cancer agent, and a method of inhibiting lactate dehydrogenase A (LDHA) and/or lactate dehydrogenase B (LDHB) activity in a cell.
Public/Granted literature
- US20210323928A1 SMALL MOLECULE INHIBITORS OF LACTATE DEHYDROGENASE AND METHODS OF USE THEREOF Public/Granted day:2021-10-21
Information query
