Methods and apparatus for communicating audio packets with ultra-low latency at high data rates from an audio source device to one or more audio output devices over a wireless personal area network (WPAN) connection, such as via a Bluetooth connection. Latency is reduced by using time-efficient audio coding and decoding, limited retransmissions, reduced time and frequency of acknowledgements, and by combining Bluetooth Classic (BTC) packets for downlink audio and downlink control with Bluetooth Low Energy (BTLE) packets for uplink control, uplink acknowledgements, and inter-device wireless communication. The number of retransmissions and packet concealments per frame cycle can be limited to an upper threshold number to satisfy a low latency requirement.