Invention Grant
- Patent Title: Phosphor-containing drug activator, suspension thereof, system containing the suspension, and methods for use
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Application No.: US16074707Application Date: 2017-02-02
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Publication No.: US11260129B2Publication Date: 2022-03-01
- Inventor: Harold Walder , Frederic A. Bourke, Jr. , Zakaryae Fathi , Wayne Beyer , Mark Oldham , Justus Adamson , Michael Nolan
- Applicant: IMMUNOLIGHT, LLC , DUKE UNIVERSITY
- Applicant Address: US MI Detroit; US NC Durham
- Assignee: IMMUNOLIGHT, LLC,DUKE UNIVERSITY
- Current Assignee: IMMUNOLIGHT, LLC,DUKE UNIVERSITY
- Current Assignee Address: US MI Detroit; US NC Durham
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- International Application: PCT/US2017/016138 WO 20170202
- International Announcement: WO2017/013650 WO 20170810
- Main IPC: A61K9/00
- IPC: A61K9/00 ; A61K41/00 ; A61K31/37 ; A61N5/06 ; A61N5/10 ; A61K45/06

Abstract:
A phosphor-containing drug activator and suspension thereof are provided. The suspension at least includes two or more phosphors capable of emitting ultraviolet and visible light upon interaction with x-rays. The two or more phosphors include Zn2SiO4:M12+ and (3Ca3 (PO4)2Ca(F, Cl)2:Sb3*, Mn2+) at a ratio NP-200:GTP-4300 of from 1:10 to 10:1, and each of the two phosphors have an ethylene cellulose coating and/or a diamond-like carbon coating. The suspension further includes a pharmaceutically acceptable carrier. A system for treating a disease in a subject in need thereof includes a) the above-noted suspension, b) a photoactivatable drug containing 8-methoxypsoralen (8-MOP or UVADEX) untethered from the two or more phosphors, c) one or more devices which infuse the photoactivatable drug and the suspension including the pharmaceutically acceptable carrier into a diseased site in the subject, and d) an x-ray source which is controlled to deliver a dose of x-rays to the subject for production of the ultraviolet light.
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