Devices, methods, and non-transitory program storage devices for spatiotemporal image noise reduction are disclosed, comprising: maintaining an accumulated image in memory; and obtaining a first plurality of multispectral images (e.g., RGB-IR images). For each image in the first plurality of multispectral images, the method may: calculate a multispectral guide image for the current image; calculate blending weights for the current image; apply the calculated blending weights to each channel of the current image to generate a denoised current image; and update the accumulated image based on pixel differences between the denoised current image and the accumulated image. In some embodiments, additional images (e.g., the accumulated image and/or other images captured prior to or after a given current image) may also be included in the denoising operations for a given current image. Finally, the method may generate a denoised output image for each input image, based on the updated accumulated image.