Example implementations relate to Speaker Orientation Audio Profile Adjustments. In some examples, a mobile computing device may include a first housing coupled to a second housing, wherein the first housing and the second housing are articulable to a plurality of configurations. The mobile computing device may include a plurality of speakers. The mobile computing device may include a sensor to detect an orientation of each of the plurality of speakers. The mobile computing device may include a memory resource comprising executable instructions to adjust an audio profile of each of the plurality of speakers based on the detected orientation of each of the plurality of speakers.