This disclosure details exemplary pillar-to-box rail-to-cab back structural joints for unibody vehicles. An exemplary structural joint of a unibody vehicle may include a pillar assembly and a box rail assembly that intersects the pillar assembly and extends continuously up to a door opening flange of the pillar assembly. The pillar assembly and box rail assembly may establish a beam-to-beam connection of the structural joint. A cab back assembly may be secured relative to the pillar assembly and the box rail assembly to establish a third portion of the structural joint. Various spot welds may be provided for joining the various components of the structural joint.