Invention Grant
- Patent Title: Chimeric antigen receptors targeting epidermal growth factor receptor variant III
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Application No.: US16255348Application Date: 2019-01-23
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Publication No.: US11267892B2Publication Date: 2022-03-08
- Inventor: Oi Kwan Wong , Joyce Ching Chou , Mathilde Brunnhilde Dusseaux , Julianne Smith , Barbra Johnson Sasu
- Applicant: Pfizer Inc.
- Applicant Address: US NY New York
- Assignee: Pfizer Inc.
- Current Assignee: Pfizer Inc.
- Current Assignee Address: US NY New York
- Agency: Proskauer Rose LLP
- Main IPC: A61K35/17
- IPC: A61K35/17 ; C12N9/64 ; A61K31/436 ; C07K16/28 ; C07K14/47 ; C07K14/725 ; A61K38/00 ; A61K39/00

Abstract:
The invention provides Chimeric Antigen Receptors (CARs) that specifically bind to EGFRvIII (Epidermal Growth Factor Receptor Variant III). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making thereof, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for using these CARs and engineered immune cells for the treatment of EGFRvIII-mediated pathologies, including cancers such as glioblastoma.
Public/Granted literature
- US20190144550A1 CHIMERIC ANTIGEN RECEPTORS TARGETING EPIDERMAL GROWTH FACTOR RECEPTOR VARIANT III Public/Granted day:2019-05-16
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