Invention Grant
- Patent Title: Affinity maturated T cell receptors and use thereof
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Application No.: US16055241Application Date: 2018-08-06
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Publication No.: US11273178B2Publication Date: 2022-03-15
- Inventor: Rachel Lea Eisenbach , Yosi Gozlan , Esther Tzehoval
- Applicant: Yeda Research and Development Co. Ltd.
- Applicant Address: IL Rehovot
- Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee Address: IL Rehovot
- Main IPC: A61K35/17
- IPC: A61K35/17 ; C07K14/725 ; C12N15/10 ; C12N15/63 ; C12N15/85 ; C12N5/0783 ; C12N5/10 ; C07K14/705
Abstract:
The present invention relates to methods and systems for increasing the affinity of a T cell receptor (TCR) to its ligand by subjecting the TCR gene to somatic hypermutation. The present invention further relates to use of affinity maturated TCRs to create T cells reactive against a selected antigen.
Public/Granted literature
- US20190031733A1 AFFINITY MATURATED T CELL RECEPTORS AND USE THEREOF Public/Granted day:2019-01-31
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