公开(公告)号：US12286439B2

公开(公告)日：2025-04-29

申请号：US17337570

申请日：2021-06-03

Applicant: Yeda Research and Development Co. Ltd. ,  Universitat de Barcelona ,  Institució Catalana de Recerca I Estudis Avançats

Inventor： Rony Seger ,  Karen Flores ,  Xavier Barril Alonso ,  Carlos Galdeano Cantador

IPC: C07D498/04 ,  A61K45/06 ,  A61P35/00

Abstract: Described herein are compounds having Formula I or Formula II: wherein each dashed line independently represents a saturated or unsaturated bond; R1 and R′1 are aryl or heteroaryl as defined herein; and R2 and R′2 are as defined herein. Further described is a method of inhibiting nuclear translocation of ERK1/2 in a cell, by contacting the cell with a compound having Formula I or Formula II. The compounds may also be for use in treating a disease or disorder associated with nuclear translocation of ERK1/2.

公开(公告)号：US20250127783A1

公开(公告)日：2025-04-24

申请号：US18694557

申请日：2022-09-23

Applicant: DANA-FARBER CANCER INSTITUTE, INC. ,  BETH ISRAEL DEACONESS MEDICAL CENTER, INC. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Shizhong KE ,  Gerburg WULF ,  Xiao Zhen ZHOU ,  Nir LONDON ,  Wenyi WEI ,  Kun Ping LU ,  Nathanael S. GRAY ,  Behnam NABET

IPC: A61K31/519 ,  A61K31/203 ,  A61K31/381 ,  A61K31/506 ,  A61K33/36 ,  A61P35/00 ,  C07K16/28

Abstract: Disclosed are methods of treating diseases or disorders mediated by dysregulated CDK4/6 and/or Pin 1 activity comprising co-administering a therapeutically effective amount of one or more CDK4/6 inhibitors, and a therapeutically effective amount of one or more Pin1 inhibitors, or a pharmaceutically acceptable salt or salts thereof

公开(公告)号：US20250127492A1

公开(公告)日：2025-04-24

申请号：US19001657

申请日：2024-12-26

Applicant: New York University ,  Yeda Research And Development Co. Ltd

Inventor： Itay KEZURER ,  Achiau LUDOMIRSKY ,  Yaron LIPMAN

IPC: A61B8/00 ,  G06N3/08 ,  G06N20/00 ,  G06T7/00 ,  G06T7/194 ,  G06T7/62 ,  G06T17/20

Abstract: A system and method for detecting at least one cardiac anomaly includes a specifically configured computer hardware arrangement configured to receive ultrasound imaging information related to a heart of a patient and to use at least one neural network trained on multiple recognition and analysis procedures to detect at least one anomaly and/or to classify a severity of at least one anomaly.

公开(公告)号：US20250122311A1

公开(公告)日：2025-04-17

申请号：US18681143

申请日：2022-08-05

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Sarel FLEISHMAN ,  Ariel TENNENHOUSE

IPC: C07K16/46 ,  C07K16/30 ,  C07K16/40

Abstract: Provided herein is a method for obtaining a humanized antibody based on a non-human antibody having an affinity to an antigen of interest, that starts from an experimental or model structure, grafts the non-human CDRs on a library of human frameworks and uses restrained/constrained atomistic simulations to relax and rank the designs by energy.

公开(公告)号：US20250092158A1

公开(公告)日：2025-03-20

申请号：US18832710

申请日：2022-08-04

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Deborah FASS ,  Sarel FLEISHMAN ,  Lev KHMELNITSKY ,  Ariel TENNENHOUSE

IPC: C07K16/40 ,  A61K39/00 ,  A61K47/68 ,  G01N33/573

Abstract: The present invention provides humanized monoclonal antibodies that specifically recognize human QSOX1 and inhibit its activity. The humanized antibodies of the present invention were designed following in-silico selection of specific variable region segments, based on their energy scores, and were produced and confirmed to function properly in binding and inhibiting human QSOX1. The present invention further provides pharmaceutical compositions comprising the humanized antibodies and methods for their use in cancer therapy and diagnosis.

公开(公告)号：US12232496B2

公开(公告)日：2025-02-25

申请号：US17040227

申请日：2019-03-21

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD

Inventor： Asaph Aharoni ,  Elisa Korenblum

IPC: A01N63/20 ,  A01G29/00 ,  A01N63/38 ,  A61K36/185 ,  A61K36/81 ,  C07D305/14 ,  C07J17/00

Abstract: Provided is a plant exudate, methods for obtaining a plant exudate by inducing the plant to secrete an exudate and systems for the collection of a plant exudate which include: one or more plant container including at least two discrete compartments each configured to accommodate a split root of a plant, the compartments being a root stimulating compartment including one or more input being in fluid communication with at least a source of a plant root stimulant, and a root exudate harvesting compartment, and a root exudate collection compartment in fluid communication with the root exudate harvesting compartment.

公开(公告)号：US20250051833A1

公开(公告)日：2025-02-13

申请号：US18721921

申请日：2022-12-26

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Sergey N. SEMENOV ,  Ekaterina V. SKORB

IPC: C12Q1/6834 ,  C12Q1/6876

Abstract: Provided herein a supramolecular assembly comprising a solid porous particle comprising a single-stranded polynucleotide encapsulated by non-covalent organic structure. Specifically, the non-covalent organic structure is melamine-cyanurate, and the single-stranded polynucleotide is ssDNA or ssRNA.

公开(公告)号：US20250032566A1

公开(公告)日：2025-01-30

申请号：US18713665

申请日：2022-12-05

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rotem SOREK ,  Erez YIRMIYA ,  Azita LEAVITT ,  Gil AMITAI ,  Jeremy Elliot GARB

IPC: A61K35/76 ,  C12N7/00

Abstract: Genetically modified phages are provided. Accordingly, there is provided a genetically modified phage comprising a polynucleotide encoding an anti-defense system polypeptide. Also provided are methods of producing and using same.

公开(公告)号：US12198012B2

公开(公告)日：2025-01-14

申请号：US18299821

申请日：2023-04-13

Applicant: QUANTUM SOURCE LABS LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Gil Semo ,  Ziv Aqua ,  Oded Melamed ,  Dan Charash ,  Serge Rosenblum ,  Barak Dayan

IPC: G06N10/40 ,  G06N10/20 ,  G21K5/00

Abstract: A quantum computing system, method, and computer readable medium involves initializing a state of a resonator-coupled quantum emitter having at least four levels arranged in an N-configuration, the N-configuration having a first ground state, a second ground state, a first excited state and a second excited state. A frequency of a first transition between the first ground state and the first excited state is tuned, a frequency of a second transition between the second ground state and the second excited state is tuned, and a frequency of a third transition between the second ground state and the first excited state is tuned. A plurality of photons are fed at a frequency corresponding to the frequency of the second transition, thereby entangling the plurality of photons to the resonator-coupled quantum emitter. Likewise, a photon at a frequency corresponding to the frequency of at least one of the first transition or the third transition is fed, thereby mapping a state of the resonator-coupled quantum emitter into a photon.

公开(公告)号：US12190206B2

公开(公告)日：2025-01-07

申请号：US18300644

申请日：2023-04-14

Applicant: QUANTUM SOURCE LABS LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Gil Semo ,  Ziv Aqua ,  Oded Melamed ,  Dan Charash ,  Serge Rosenblum ,  Barak Dayan

IPC: G06N10/40 ,  G02F1/313 ,  G21K1/00 ,  H01S3/042

Abstract: A quantum computing system, method and computer readable medium involve a vacuum enclosure for sustaining a vacuum below 10−3 millibar, optical resonators tuned to a resonance of an alkali atom, and a trapping laser for maintaining the alkali atom within a mode of the optical resonators. An atom excitation laser induces photon emissions, a plurality of waveguides couple photons to and from the optical resonators, and a plurality of detectors detect a presence or absence of an atom-resonator coupling. A processor receives output signals from the detectors and controls optical switches for switching between two or more of the plurality of waveguides.