- 专利标题： Treatment of cancer with larazotide derivatives in combination with immune checkpoint inhibitors
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申请号： US17239056申请日： 2021-04-23
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公开(公告)号： US11278587B2公开(公告)日： 2022-03-22
- 发明人: Jay Madan , Sandeep Laumas
- 申请人： 9 METERS BIOPHARMA, INC. , Institut Gustave Roussy
- 申请人地址： US NC Raleigh; FR Villejuif
- 专利权人： 9 METERS BIOPHARMA, INC.,Institut Gustave Roussy
- 当前专利权人： 9 METERS BIOPHARMA, INC.,Institut Gustave Roussy
- 当前专利权人地址： US NC Raleigh; FR Villejuif
- 代理机构： Morgan, Lewis & Bockius LLP
- 主分类号： A61K38/08
- IPC分类号： A61K38/08 ; A61K9/00 ; A61P35/00 ; A61K39/395 ; A61K39/00
摘要：
The present invention provides compositions and methods for treating a patient having cancer, as well as methods for potentiating an immune checkpoint inhibitor therapy. The methods comprise administering larazotide or a derivative thereof such as (d)-larazotide to a subject in need, including subjects undergoing checkpoint inhibitor therapy, and subjects scheduled to undergo immune checkpoint inhibitor therapy.
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