A control method of a handheld electronic device adapted to a handheld electronic device is provided. The handheld electronic device includes a touch panel. The control method includes the steps of: dividing the touch panel into two areas, and defining a trigger region in each area; configuring the touch panel to detect a touch point; and determining whether the touch point is located in the trigger region or not, and when the touch point is located in the trigger region, forming a shielding region corresponding to the trigger region; and when the touch point is not located in the trigger region, repeatedly detecting the touch point.