- 专利标题: Cell penetrating peptide (CPP)-mediated EV loading
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申请号: US16317455申请日: 2017-07-10
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公开(公告)号: US11298319B2公开(公告)日: 2022-04-12
- 发明人: Oscar Wiklander , Per Lundin , Dhanu Gupta
- 申请人: Evox Therapeutics Ltd
- 申请人地址: GB Oxford
- 专利权人: Evox Therapeutics Ltd
- 当前专利权人: Evox Therapeutics Ltd
- 当前专利权人地址: GB Oxford
- 代理机构: Cooley LLP
- 代理商 Matthew Pavao; (Chris) Chun L. Yu
- 优先权: GB1611988 20160711
- 国际申请: PCT/EP2017/067297 WO 20170710
- 国际公布: WO2018/011153 WO 20180118
- 主分类号: A61K47/69
- IPC分类号: A61K47/69 ; A61K9/127 ; A61K47/61 ; A61K47/64 ; A61K47/54 ; A61K9/50 ; C12N15/88
摘要:
The present invention relates to methods for loading extracellular vesicles (EVs) with a pharmacological agent. The invention discloses the use of cell-penetrating peptides as carriers into EVs, using either a non-covalent or covalent loading approach. Furthermore, the present invention pertains to medical uses and compositions comprising such pharmacological agent-loaded EVs.
公开/授权文献
- US20190388347A1 CELL PENETRATING PEPTIDE (CPP)-MEDIATED EV LOADING 公开/授权日:2019-12-26
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