- 专利标题: Prodrugs of substituted triazole derivatives and uses thereof
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申请号: US16758742申请日: 2018-10-17
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公开(公告)号: US11298367B2公开(公告)日: 2022-04-12
- 发明人: Marie-Pierre Collin-Kroepelin , Peter Kolkhof , Thomas Neubauer , Chantal Fuerstner , Elisabeth Pook , Matthias Beat Wittwer , Carsten Schmeck , Pierre Wasnaire , Heiko Schirmer , Hana Cernecka , Karoline Droebner , Hanna Tinel , Anja Buchmueller , Thomas Mondritzki , Axel Kretschmer , Klemens Lustig , Robert Fricke , Guillaume Levilain , Ursula Krenz , Norbert Witowski
- 申请人: Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft
- 申请人地址: DE Leverkusen; DE Berlin
- 专利权人: Bayer Aktiengesellschaft,Bayer Pharma Aktiengesellschaft
- 当前专利权人: Bayer Aktiengesellschaft,Bayer Pharma Aktiengesellschaft
- 当前专利权人地址: DE Leverkusen; DE Berlin
- 代理机构: McBee Moore & Vanik IP, LLC
- 优先权: EP17197935 20171024
- 国际申请: PCT/EP2018/078364 WO 20181017
- 国际公布: WO2019/081292 WO 20190502
- 主分类号: A61K31/675
- IPC分类号: A61K31/675 ; A61P13/12 ; A61K45/06 ; C07F9/6558
摘要:
The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl ]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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