- 专利标题： Method of producing proteins in filamentous fungi with decreased CLR2 activity
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申请号： US15779595申请日： 2016-12-02
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公开(公告)号： US11299522B2公开(公告)日： 2022-04-12
- 发明人: Stefan Haefner , Andreas Thywissen , Holger Hartmann , Nico Boehmer
- 申请人： BASF SE
- 申请人地址： DE Ludwigshafen am Rhein
- 专利权人： BASF SE
- 当前专利权人： BASF SE
- 当前专利权人地址： DE Ludwigshafen am Rhein
- 代理机构： Armstrong Teasdale LLP
- 优先权： EP15197497 20151202
- 国际申请： PCT/EP2016/079526 WO 20161202
- 国际公布： WO2017/093450 WO 20170608
- 主分类号： C12P21/00
- IPC分类号： C12P21/00 ; C12N9/14 ; C12N1/15 ; C07K14/37 ; C12N9/16 ; C12N9/24 ; C12N15/80
摘要：
The present invention relates to a method of producing a recombinant polypeptide a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 2 (CLR2) and to express said recombinant polypeptide. The method further relates to a filamentous fungus Myceliophthora thermophila, which is genetically modified to decrease or eliminate the activity of CLR2 and the use of this filamentous fungus in the production of a recombinant polypeptide.
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