A database system could include a first database engine, a second database engine, and a replication engine. The database system could also include processors configured to perform operations. The operations could involve obtaining indicators that are respectively associated with performance issues that can occur in the database system, each indicator defining one or more conditions that, when satisfied, cause the indicator to become active. The operations could also involve obtaining mappings between: (i) at least some of the indicators, and (ii) remediation subroutines. The operations could additionally involve receiving operational data related to the first database engine, the second database engine, or the replication engine; determining, based on the operational data and the conditions defined by the indicators, that a particular indicator is active; determining, based on the mappings, that the particular indicator has an associated remediation subroutine; and executing the associated remediation subroutine.