A ligation clip removal device includes an elongate body, a tool assembly, and a drive member. The tool assembly is supported on a distal portion of the elongate body and includes a first jaw and a second jaw pivotably supported in relation to the first jaw between an open position and a clamped position. Each of the first and second jaws includes a clip engagement surface that defines a recess having a longitudinal portion and a first transverse portion that intersects the longitudinal portion. The longitudinal portions of the recesses are configured to receive a leg of a ligation clip and the first transverse portion of the recess is configured to receive a portion of a boss of the ligation clip. The drive member is engaged with and movable in relation to the tool assembly to move the first and second jaws between the open and clamped positions.