Invention Grant
- Patent Title: Compositions and methods for organ specific delivery of nucleic acids
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Application No.: US17473863Application Date: 2021-09-13
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Publication No.: US11304911B2Publication Date: 2022-04-19
- Inventor: Qiang Cheng , Tuo Wei , Daniel J. Siegwart
- Applicant: The Board of Regents of the University of Texas System
- Applicant Address: US TX Austin
- Assignee: The Board of Regents of the University of Texas System
- Current Assignee: The Board of Regents of the University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Parker Highlander PLLC
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; A61K9/51 ; A61K48/00 ; C12N9/22 ; C12N15/11 ; C12N15/113
Abstract:
The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
Public/Granted literature
- US20210401762A1 COMPOSITIONS AND METHODS FOR ORGAN SPECIFIC DELIVERY OF NUCLEIC ACIDS Public/Granted day:2021-12-30
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