In a clamping device (1), in particular vice, the clamping device comprising: a housing (2) which is U-shaped in cross-section and in which one or two guideways (8) extending in a linear direction are incorporated, at least one base jaw (11) which is mounted in the guideway (8) and in which an internal thread (12) is provided, and a drive spindle (9) which is rotatably mounted in the respective housing (2), is arranged parallel to the guideway (8) and is drivably coupled to the respective base jaw (11), the threads (10) worked into the drive spindle (9), through which the torques from the crank are transmitted for the linear displacement of the base jaws (11), should be permanently encapsulated in a watertight and airtight manner irrespective of the position of the base jaws (11) or the drive spindle (9), and on the other hand the adjustment travel (Δs) of the base jaws (11) or clamping jaws (13) should be as large as possible in order to clamp workpieces with configurations that can be completely different without the need for time-consuming and complicated conversion measures. This is achieved in that a right-hand thread and a left-hand thread (10) are worked onto the drive spindle (9) in regions, in that the respective thread (10) of the drive spindle (9) is enclosed or encapsulated by a cover sleeve (21), in that the cover sleeve (21) has a right-hand thread and a left-hand internal thread (22), which are drivably coupled to the respective thread (10) of the drive spindle (9), in that a right-hand and a left-hand external thread (23), which is in engagement with the respective internal thread (12) of the base jaw (11), is worked on to the cover sleeve (21).