The invention relates to an ophthalmic pressure control system, comprising: a pressure regulator having an input port and an output port, and an infusion line having a proximal end and a distal end, the proximal end being connected to the output port of the pressure regulator, and the distal end being detachably connected to an ophthalmic irrigation module. Further, the system includes a control unit driving the pressure regulator for controlling an infusion fluid pressure at a distal end of the ophthalmic irrigation module. The control unit is arranged for performing a fluid calibration process including a step of determining a fluid impedance of the ophthalmic irrigation module. The infusion line is associated with a kit of parts including a first and a second ophthalmic irrigation device, or the ophthalmic irrigation module is an ophthalmic irrigation device for surgical use.