An autonomous cargo delivery aircraft operable to transition between thrust-borne lift in a VTOL orientation and wing-borne lift in a biplane orientation. The aircraft includes a fuselage having an aerodynamic shape with a leading edge, a trailing edge and first and second sides. First and second wings are coupled to the fuselage proximate the first and second sides, respectively. A distributed thrust array includes a first pair of propulsion assemblies coupled to the first wing and a second pair of propulsion assemblies coupled to the second wing. A flight control system is operably associated with the distributed thrust array and configured to independently control each of the propulsion assemblies. The first side of the fuselage includes a door configured to provide access to a cargo bay disposed within the fuselage from an exterior of the aircraft with a predetermined clearance relative to the first pair of propulsion assemblies.