- 专利标题: Co-flow injection for serial crystallography
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申请号: US15930239申请日: 2020-05-12
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公开(公告)号: US11318487B2公开(公告)日: 2022-05-03
- 发明人: Alexandra Ros , Daihyun Kim , Austin Echelmeier , Jorvani Cruz Villarreal , Diandra Doppler , Richard Kirian , Reza Nazari
- 申请人: Alexandra Ros , Daihyun Kim , Austin Echelmeier , Jorvani Cruz Villarreal , Diandra Doppler , Richard Kirian , Reza Nazari
- 申请人地址: US AZ Phoenix; US AZ Mesa; US AZ Tempe; US AZ Tempe; US AZ Scottsdale; US AZ Tempe; US AZ Tempe
- 专利权人: Alexandra Ros,Daihyun Kim,Austin Echelmeier,Jorvani Cruz Villarreal,Diandra Doppler,Richard Kirian,Reza Nazari
- 当前专利权人: Alexandra Ros,Daihyun Kim,Austin Echelmeier,Jorvani Cruz Villarreal,Diandra Doppler,Richard Kirian,Reza Nazari
- 当前专利权人地址: US AZ Phoenix; US AZ Mesa; US AZ Tempe; US AZ Tempe; US AZ Scottsdale; US AZ Tempe; US AZ Tempe
- 代理机构: Michael Best & Friedrich LLP
- 主分类号: B05B7/04
- IPC分类号: B05B7/04 ; G01N23/20008
摘要:
Systems and methods for performing serial crystallography by providing an aqueous suspension of a crystal sample to a T-junction at a first flow rate and providing an immiscible oil fluid to the T-junction at a second flow rate. The aqueous suspension and the oil are combined at the T-junction to produce a co-flow output fluid including a parallel co-flow of the aqueous suspension and the oil in the same output channel. The co-flow output fluid is ejected as a jet stream through a nozzle and the sample flow rate in the crystal sample in the jet stream is adjusted by adjusting the first flow rate of the aqueous suspension and the second flow rate of the oil. By combining the aqueous sample and the oil in this manner, the output of the jet stream can be regulated for compatibility with X-ray free electron laser serial crystallography.