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公开(公告)号：US11318487B2
公开(公告)日：2022-05-03
申请号：US15930239
申请日：2020-05-12
申请人： Alexandra Ros , Daihyun Kim , Austin Echelmeier , Jorvani Cruz Villarreal , Diandra Doppler , Richard Kirian , Reza Nazari
发明人： Alexandra Ros , Daihyun Kim , Austin Echelmeier , Jorvani Cruz Villarreal , Diandra Doppler , Richard Kirian , Reza Nazari
IPC分类号： B05B7/04 , G01N23/20008
摘要： Systems and methods for performing serial crystallography by providing an aqueous suspension of a crystal sample to a T-junction at a first flow rate and providing an immiscible oil fluid to the T-junction at a second flow rate. The aqueous suspension and the oil are combined at the T-junction to produce a co-flow output fluid including a parallel co-flow of the aqueous suspension and the oil in the same output channel. The co-flow output fluid is ejected as a jet stream through a nozzle and the sample flow rate in the crystal sample in the jet stream is adjusted by adjusting the first flow rate of the aqueous suspension and the second flow rate of the oil. By combining the aqueous sample and the oil in this manner, the output of the jet stream can be regulated for compatibility with X-ray free electron laser serial crystallography.
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公开(公告)号：US20230243765A1
公开(公告)日：2023-08-03
申请号：US18295761
申请日：2023-04-04
申请人： Alexandra Ros , Daihyun Kim , Diandra Doppler , Jorvani Cruz Villarreal , Richard Kirian , Reza Nazari , Sahir Gandhi
发明人： Alexandra Ros , Daihyun Kim , Diandra Doppler , Jorvani Cruz Villarreal , Richard Kirian , Reza Nazari , Sahir Gandhi
IPC分类号： G01N23/20025 , G01N23/201 , B01L3/02 , G01N35/10 , B01L3/00
CPC分类号： G01N23/20025 , G01N23/201 , B01L3/0241 , G01N35/1016 , B01L3/502715 , G01N2223/30 , G01N2223/604 , G01N2223/612 , G01N2223/637 , G01N2223/1016 , G01N2223/203 , G01N2223/054 , G01N2035/1034 , B01L2300/0645
摘要： A single-piece hybrid droplet generator and nozzle component for serial crystallography. The single-piece hybrid droplet generator component including an internally-formed droplet-generation channel, an internally-formed sample channel, a nozzle, and a pair of electrode chambers. The droplet-generation channel extends from a first fluid inlet opening to the nozzle. The sample channel extends from a second fluid inlet opening to the droplet-generation channel and joins the droplet-generation channel at a junction. The nozzle is configured to eject a stream of segmented aqueous droplets in a carrier fluid from the droplet-generation channel through a nozzle opening of the single-piece component. The pair of electrode chambers are positioned adjacent to the droplet-generation channel near the junction between the droplet-generation channel and the sample channel. The timing of sample droplets in the stream of fluid ejected through the nozzle is controlled by applying a triggering signal to electrodes positioned in the electrode chambers of the single-piece component.
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公开(公告)号：US11624718B2
公开(公告)日：2023-04-11
申请号：US15930313
申请日：2020-05-12
申请人： Alexandra Ros , Daihyun Kim , Diandra Doppler , Jorvani Cruz Villarreal , Richard Kirian , Reza Nazari , Sahir Gandhi
发明人： Alexandra Ros , Daihyun Kim , Diandra Doppler , Jorvani Cruz Villarreal , Richard Kirian , Reza Nazari , Sahir Gandhi
IPC分类号： B01L3/00 , G01N23/20025 , G01N23/201 , B01L3/02 , G01N35/10 , G01N23/20
摘要： A single-piece hybrid droplet generator and nozzle component for serial crystallography. The single-piece hybrid droplet generator component including an internally-formed droplet-generation channel, an internally-formed sample channel, a nozzle, and a pair of electrode chambers. The droplet-generation channel extends from a first fluid inlet opening to the nozzle. The sample channel extends from a second fluid inlet opening to the droplet-generation channel and joins the droplet-generation channel at a junction. The nozzle is configured to eject a stream of segmented aqueous droplets in a carrier fluid from the droplet-generation channel through a nozzle opening of the single-piece component. The pair of electrode chambers are positioned adjacent to the droplet-generation channel near the junction between the droplet-generation channel and the sample channel. The timing of sample droplets in the stream of fluid ejected through the nozzle is controlled by applying a triggering signal to electrodes positioned in the electrode chambers of the single-piece component.
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公开(公告)号：US20220112079A1
公开(公告)日：2022-04-14
申请号：US17497675
申请日：2021-10-08
申请人： Alexandra Ros , John Spence , Diandra Doppler , Garrett Nelson , Richard Kirian , Reza Nazari , Ana Egatz-Gomez , Mukul Sonker , Mohammad Rabbani
发明人： Alexandra Ros , John Spence , Diandra Doppler , Garrett Nelson , Richard Kirian , Reza Nazari , Ana Egatz-Gomez , Mukul Sonker , Mohammad Rabbani
摘要： A microfluidic device for use in a serial crystallography apparatus includes a nozzle having an inlet, an outlet, and a first snap engagement feature. The microfluidic device further includes a fiber holder having an outlet and a second snap engagement feature. The first snap engagement feature is configured to engage the second snap engagement feature to removably couple the nozzle to the fiber holder. The outlet of the fiber holder is aligned with the inlet of the nozzle when the first snap engagement feature is coupled to the second snap engagement feature.
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公开(公告)号：US20210001359A1
公开(公告)日：2021-01-07
申请号：US16918807
申请日：2020-07-01
申请人： Richard Kirian , Reza Nazari , Uwe Weierstall , Ronald Adrian
发明人： Richard Kirian , Reza Nazari , Uwe Weierstall , Ronald Adrian
摘要： A nozzle includes a chamber, a first channel formed in the nozzle, and a first passageway extending between the first channel and the chamber. The first passageway defines a first passageway axis. The nozzle also includes a second channel formed in the nozzle and a second passageway extending between the second channel and the chamber. The second passageway defines a second passageway axis, and the first passageway axis is not concentric with the second passageway axis.
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6.发明申请Extracts and Compounds from Ficus Benghalensis for Increasing Hair Growth and Decreasing Hair Loss 审中-公开来自榕树的提取物和化合物用于增加头发生长和减少脱发公开(公告)号：US20120035119A1
公开(公告)日：2012-02-09
申请号：US13236185
申请日：2011-09-19
摘要： This application discloses natural product extracts and compounds from an aerial root of a Ficus plant, such as Ficus benghalensis. The application also discloses the use of natural product extracts and compounds from Ficus plants for increasing hair growth and decreasing hair loss. Synthetic formulations comprising various compounds identified in the natural product extracts and methods of use thereof are further disclosed.
摘要翻译： 本申请公开了榕属植物的天根产物提取物和化合物，例如榕树（Ficus benghalensis）。 该申请还公开了使用来自榕属植物的天然产物提取物和化合物来增加头发生长和减少脱发。 还公开了包含在天然产物提取物中鉴定的各种化合物及其使用方法的合成制剂。
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公开(公告)号：US20110306546A1
公开(公告)日：2011-12-15
申请号：US13083203
申请日：2011-04-08
申请人： Antonio Armani , Sara Armani , Charitha Seneviratne , Reza Nazari
发明人： Antonio Armani , Sara Armani , Charitha Seneviratne , Reza Nazari
CPC分类号： A61K38/1825 , A61K38/1703 , A61K38/1858 , A61K38/1875 , A61K38/30 , A61K2300/00
摘要： The invention provides compositions and methods for increasing hair growth and decreasing hair loss. In one embodiment, the compositions comprise a plurality of hair growth agents. Optionally, the hair growth agents are selected from the group consisting of: IGF-1, FGF-2, FGF-10, PDGF-AA, Wnt-3a, noggin, ephrin-A3, sonic hedgehog (SHH), BMP-6 and hypoxanthine.
摘要翻译： 本发明提供用于增加头发生长和减少脱发的组合物和方法。 在一个实施方案中，组合物包含多种毛发生长剂。 任选地，毛发生长剂选自：IGF-1，FGF-2，FGF-10，PDGF-AA，Wnt-3a，头蛋白，ephrin-A3，声波刺猬（SHH），BMP-6和 次黄嘌呤
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公开(公告)号：US20110305671A1
公开(公告)日：2011-12-15
申请号：US13083182
申请日：2011-04-08
申请人： Antonio Armani , Sara Armani , Charitha Seneviratne , Reza Nazari
发明人： Antonio Armani , Sara Armani , Charitha Seneviratne , Reza Nazari
CPC分类号： A61K35/36 , A61K9/0019 , A61K9/06 , A61K38/177 , A61K38/1825 , A61K38/1858 , A61K38/1875 , A61K38/19 , A61K38/30 , A61K47/36 , C12N5/0627 , C12N2500/40 , C12N2501/105 , C12N2501/115 , C12N2501/119 , C12N2501/135 , C12N2501/155 , C12N2501/41 , C12N2501/415 , C12N2501/998 , C12N2533/80 , A61K2300/00
摘要： The application describes a method of generating a hair follicle, comprising administering a composition comprising epidermal matrix cells, dermal papilla cells, dermal sheath cells and outer root sheath cells to the scalp of a mammal. The composition may optionally be administered with a hair growth agent and/or a carrier. The application also describes a composition comprising epidermal matrix cells, dermal papilla cells, dermal sheath cells and outer root sheath cells and the use of the composition to generate hair follicles.
摘要翻译： 本申请描述了一种产生毛囊的方法，包括向哺乳动物的头皮施用包含表皮基质细胞，真皮乳头细胞，真皮鞘细胞和外根鞘细胞的组合物。 组合物可任选地与毛发生长剂和/或载体一起施用。 本申请还描述了包含表皮基质细胞，真皮乳头细胞，真皮鞘细胞和外根鞘细胞的组合物，以及该组合物用于产生毛囊的组合物。
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9.发明授权Extracts and compounds from Ficus benghalensis for increasing hair growth and decreasing hair loss 有权来自榕树的提取物和化合物用于增加头发生长和减少脱发公开(公告)号：US08617622B2
公开(公告)日：2013-12-31
申请号：US13051543
申请日：2011-03-18
申请人： Antonio Armani , Sara Armani , Charitha Seneviratne , Reza Nazari
发明人： Antonio Armani , Sara Armani , Charitha Seneviratne , Reza Nazari
IPC分类号： A61K36/00
摘要： This application discloses natural product extracts and compounds from an aerial root of a Ficus plant, such as Ficus benghalensis. The application also discloses the use of natural product extracts and compounds from Ficus plants for increasing hair growth and decreasing hair loss. Methods of producing the extracts and isolating the compounds are further disclosed.
摘要翻译： 本申请公开了榕属植物的天根产物提取物和化合物，例如榕树（Ficus benghalensis）。 该申请还公开了使用来自榕属植物的天然产物提取物和化合物来增加头发生长和减少脱发。 进一步公开生产提取物和分离化合物的方法。
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10.发明申请Extracts and Compounds from Ficus Benghalensis for Increasing Hair Growth and Decreasing Hair Loss 有权来自榕树的提取物和化合物用于增加头发生长和减少脱发公开(公告)号：US20120128796A1
公开(公告)日：2012-05-24
申请号：US13051543
申请日：2011-03-18
申请人： Antonio Armani , Sara Armani , Charitha Seneviratne , Reza Nazari
发明人： Antonio Armani , Sara Armani , Charitha Seneviratne , Reza Nazari
IPC分类号： A61K36/60 , A61K31/7016 , A61K31/7028 , A61P17/14
摘要： This application discloses natural product extracts and compounds from an aerial root of a Ficus plant, such as Ficus benghalensis. The application also discloses the use of natural product extracts and compounds from Ficus plants for increasing hair growth and decreasing hair loss. Methods of producing the extracts and isolating the compounds are further disclosed.
摘要翻译： 本申请公开了榕属植物的天根产物提取物和化合物，例如榕树（Ficus benghalensis）。 该申请还公开了使用来自榕属植物的天然产物提取物和化合物来增加头发生长和减少脱发。 进一步公开生产提取物和分离化合物的方法。
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