Invention Grant
- Patent Title: Anti-rho GTPase conformational single domain antibodies and uses thereof
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Application No.: US16703343Application Date: 2019-12-04
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Publication No.: US11319381B2Publication Date: 2022-05-03
- Inventor: Aurelien Olichon , Laura Keller , Gilles Favre , Nicolas Bery , Patrick Chinestra
- Applicant: INSERM (Institut National de la Sante et de la Recherche Medicale) , Universite Paul Sabatier Toulouse III , Institut Claudius Regaud
- Applicant Address: FR Paris; FR Toulouse; FR Toulouse
- Assignee: INSERM (Institut National de la Sante et de la Recherche Medicale),Universite Paul Sabatier Toulouse III,Institut Claudius Regaud
- Current Assignee: INSERM (Institut National de la Sante et de la Recherche Medicale),Universite Paul Sabatier Toulouse III,Institut Claudius Regaud
- Current Assignee Address: FR Paris; FR Toulouse; FR Toulouse
- Agency: WCF IP
- Priority: EP15305160 20150203
- Main IPC: C07K16/40
- IPC: C07K16/40 ; C12N15/85 ; C12N15/11 ; C12N15/13 ; C12N15/09
Abstract:
The present invention relates to active form specific anti-Rho GTPase conformational single domain antibodies and their uses in particular in the therapeutic and diagnostic fields. In particular, the present invention relates to a single domain antibody wherein the amino acid sequences of CDR1-IMGT, CDR2-IMGT and CDR3-IMGT have at least 90% of identity with the amino acid sequences of the CDR1-IMGT, CDR2-IMGT and CDR3-IMGT of the H12, B6, 4P75, 4SP1, 4SNP36, 4SNP61, 5SP10, 5SP11, 5SP58, 5SNP47, 5SNP48, 5SNP65, B20, B15, B5, B71, E3, A6, G12, NB61, 212B, 111B or 404F (hs2dAb) single domain antibody which are defined in Table B.
Public/Granted literature
- US20210171658A1 ANTI-RHO GTPASE CONFORMATIONAL SINGLE DOMAIN ANTIBODIES AND USES THEREOF Public/Granted day:2021-06-10
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