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    Reaction processor
    3.
    发明授权
    Reaction processor 有权

    公开(公告)号：US12186756B2

    公开(公告)日：2025-01-07

    申请号：US17243770

    申请日：2021-04-29

    Applicant: Go!Foton, Inc.

    Inventor： Takashi Fukuzawa

    IPC: B01L7/00 ,  B01L3/00 ,  C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  C12Q1/6844 ,  C12Q1/686

    Abstract: A reaction processor includes: a vessel installation unit for installing a reaction processing vessel provided with a channel formed in a substrate; a high temperature heater and a medium temperature heater for adjusting the temperature of the channel of the reaction processing vessel; a vessel alignment mechanism for adjusting the position of the reaction processing vessel 10; and a housing that has a housing main unit and a cover portion capable of being opened and closed with respect to the housing main unit and that houses the vessel installation unit, the high temperature heater, the medium temperature heater, and the vessel alignment mechanism. In conjunction with the state of the cover portion being changed from an open state to a closed state, the vessel alignment mechanism aligns the reaction processing vessel such that the reaction processing vessel can be heated by the high temperature heater and the medium temperature heater.

    Method for producing hydroxy-L-pipecolic acid
    4.
    发明授权
    Method for producing hydroxy-L-pipecolic acid 有权

    公开(公告)号：US12173330B2

    公开(公告)日：2024-12-24

    申请号：US18157226

    申请日：2023-01-20

    Applicant: API CORPORATION

    Inventor： Ryoma Miyake ,  Hiroshi Kawabata

    IPC: C12N9/02 ,  C12N9/06 ,  C12N9/10 ,  C12P17/12 ,  C12N15/09

    Abstract: A method of producing high-purity hydroxy-L-pipecolic acids that includes allowing an L-pipecolic acid hydroxylase, a microorganism or cell having the ability to produce the enzyme, a processed product of the microorganism or cell, and/or a culture liquid comprising the enzyme and obtained by culturing the microorganism or cell, to act on L-pipecolic acid as a substrate in the presence of 2-oxoglutaric acid and ferrous ion, wherein the L-pipecolic acid hydroxylase (1) acts on L-pipecolic acid in the presence of 2-oxoglutaric acid and ferrous ion to add a hydroxy group to the carbon atom at positions 3, 4, and/or 5 of L-pipecolic acid; and (2) has a catalytic efficiency (kcat/Km) with L-proline that is equal to or less than 7 times the catalytic efficiency (kcat/Km) with L-pipecolic acid.

    Method For Promoting Differentiation Of Pluripotent Stem Cells By Reducing Undifferentiated State Thereof
    6.
    发明申请
    Method For Promoting Differentiation Of Pluripotent Stem Cells By Reducing Undifferentiated State Thereof 有权

    公开(公告)号：US20240384234A1

    公开(公告)日：2024-11-21

    申请号：US18787081

    申请日：2024-07-29

    Applicant: KEIO UNIVERSITY

    Inventor： Minoru KO

    IPC: C12N5/077 ,  C12N5/071 ,  C12N5/0793 ,  C12N15/09 ,  C12N15/113

    Abstract: In related-art methods of differentiating pluripotent stem cells into a desired cell type, there has not been established a differentiation induction method using human ES/iPS cells and being highly efficient. Many attempts have been made, including a stepwise differentiation induction method based on the control of culture conditions or the addition of, for example, various cell growth factors/differentiation factors to a culture solution, but the use of complicated culture steps is a big problem. A method of inducing differentiation into a desired cell type within a short period of time and with high efficiency by use of a pluripotent stem cell that actively undergoes cell differentiation, which is obtained by reducing an undifferentiated state of the pluripotent stem cell, has been developed, and thus the present invention has been completed.

    Method for discriminating a microorganism
    8.
    发明授权
    Method for discriminating a microorganism 有权

    公开(公告)号：US12092645B2

    公开(公告)日：2024-09-17

    申请号：US18059404

    申请日：2022-11-28

    Applicant: SHIMADZU CORPORATION ,  MEIJO UNIVERSITY

    Inventor： Hiroto Tamura ,  Naomi Yamamoto ,  Teruyo Kato ,  Keisuke Shima ,  Shinji Funatsu

    IPC: G01N33/68 ,  C12Q1/04 ,  C12N15/09

    CPC classification number: G01N33/6848 ,  C12Q1/04 ,  C12N15/09 ,  G01N2333/195 ,  G01N2560/00

    Abstract: To provide a method for discriminating a microorganism by selecting and using a marker protein capable of reproducibly and quickly discriminating a bacterial species of the genus Listeria. The method for discriminating a microorganism according to the present invention includes: a step of subjecting a sample containing a microorganism to mass spectrometry to obtain a mass spectrum; a reading step of reading a mass-to-charge ratio m/z of a peak derived from a marker protein from the mass spectrum; and a discrimination step of discriminating which bacterial species of Listeria bacteria the microorganism contained in the sample contains based on the mass-to-charge ratio m/z, in which at least one of 17 ribosomal proteins L3, L4, L23, L2, L24, L6, L18, S5, L15, S13, S11, L10, L21, L13, S9, L31, S16 is used as the marker protein and particularly at least one of 8 ribosomal proteins L24, L6, L18, L15, S9, L31, S16 among the 17 ribosomal proteins is used.

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