- 专利标题: Sustained drug release sheet for treating nerve injury
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申请号: US16082594申请日: 2017-03-06
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公开(公告)号: US11324704B2公开(公告)日: 2022-05-10
- 发明人: Hiroyuki Tanaka , Kiyoshi Okada , Hideki Yoshikawa , Koji Suzuki , Mitsuhiro Ebara
- 申请人: OSAKA UNIVERSITY , NATIONAL INSTITUTE FOR MATERIALS SCIENCE , NIPPON ZOKI PHARMACEUTICAL CO., LTD.
- 申请人地址: JP Suita; JP Tsukuba; JP Osaka
- 专利权人: OSAKA UNIVERSITY,NATIONAL INSTITUTE FOR MATERIALS SCIENCE,NIPPON ZOKI PHARMACEUTICAL CO., LTD.
- 当前专利权人: OSAKA UNIVERSITY,NATIONAL INSTITUTE FOR MATERIALS SCIENCE,NIPPON ZOKI PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: JP Suita; JP Tsukuba; JP Osaka
- 代理机构: Oliff PLC
- 优先权: JP2016-043873 20160307,JP2017-008913 20170120,JP2017-037270 20170228
- 国际申请: PCT/JP2017/008730 WO 20170306
- 国际公布: WO2017/154822 WO 20170914
- 主分类号: A61K9/70
- IPC分类号: A61K9/70 ; A61K47/34 ; A61K47/36 ; A61K31/714 ; A61K35/36 ; A61K45/00 ; A61K38/18 ; A61P25/02 ; A61K47/32
摘要:
Provided is a sustained release sheet that includes a drug for treating nerve injury, wherein the sheet is applied to a nerve injury site, can maintain a high concentration of the drug over a long period, and promotes nerve regeneration without stimulating the nerves, even when the sheet is implanted in the periphery of the nerve injury site. Also provided is a production method for the sheet. This sustained drug release sheet for treating nerve injury is a sheet comprising a non-woven fabric that is formed from nanofibers each containing a drug such as vitamin B12 and a biocompatible polymer such as a biodegradable aliphatic polyester, and is implanted in the periphery of the nerve injury site to promote nerve regeneration.
公开/授权文献
- US20190083415A1 SUSTAINED DRUG RELEASE SHEET FOR TREATING NERVE INJURY 公开/授权日:2019-03-21
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