A system for maintaining a desired pressure difference between a first pressure within a chamber and a reference pressure at a reference space. The system may include a peristaltic pump located along a duct that connects the chamber with the reference space. The system may further include a pressure sensor for monitoring an actual pressure difference between the first pressure within the chamber and the reference pressure at the reference space. The system may also include a controller for receiving a signal from the pressure sensor for determining the actual pressure difference from the pressure sensor and for operating the peristaltic pump, in accordance with the actual pressure difference and the desired pressure difference, to increase, decrease or leave unchanged the pressure within the chamber so as to maintain the actual pressure difference within predetermined proximity to the desired pressure difference.