![Method for preparing 3-[(4S)-8-bromo-1-methyl-6-(pyridin-2-yl)-4H-imidazo[ 1,2-a][1,4]benzodiazepin-4-yl]-propionic acid methyl ester, and compounds useful in said method](/docs/US/2022-05-10/US11325911B2/abs.jpg.600x600.jpg)
- Patent Title: Method for preparing 3-[(4S)-8-bromo-1-methyl-6-(pyridin-2-yl)-4H-imidazo[ 1,2-a][1,4]benzodiazepin-4-yl]-propionic acid methyl ester, and compounds useful in said method
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Application No.: US16754821Application Date: 2018-10-11
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Publication No.: US11325911B2Publication Date: 2022-05-10
- Inventor: Carles Sánchez Casals , Alicia Dobarro Rodríguez
- Applicant: MOEHS IBERICA, S.L.
- Applicant Address: ES Rubí-Barcelona
- Assignee: MOEHS IBERICA, S.L.
- Current Assignee: MOEHS IBERICA, S.L.
- Current Assignee Address: ES Rubí-Barcelona
- Agency: Casimir Jones, S.C.
- Agent Tristan A. Fuierer
- Priority: ESES201731210 20171013
- International Application: PCT/EP2018/077669 WO 20181011
- International Announcement: WO2019/072944 WO 20190418
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61P25/20 ; C07D401/04 ; C07D413/14
![Method for preparing 3-[(4S)-8-bromo-1-methyl-6-(pyridin-2-yl)-4H-imidazo[ 1,2-a][1,4]benzodiazepin-4-yl]-propionic acid methyl ester, and compounds useful in said method](/abs-image/US/2022/05/10/US11325911B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to a method for preparing 3-[(4S)-8-bromo-1-methyl-6-(pyridin-2-yl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]-propionic acid methyl ester starting from 3-[(3S)-7-bromo-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-[1,4]-benzodiazepin-3-yl] propionic acid methyl ester, and novel compounds useful as intermediates in said method, i.e., (3S)-3-[7-bromo-2-(2,2-dimethoxypropylamino)-5-pyridin-2-yl-3H-benzo[e] [1,4]diazepin-3-yl]propionic acid methyl ester.
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