公开(公告)号：US11325911B2

公开(公告)日：2022-05-10

申请号：US16754821

申请日：2018-10-11

Applicant: MOEHS IBERICA, S.L.

Inventor： Carles Sánchez Casals ,  Alicia Dobarro Rodríguez

IPC: C07D487/04 ,  A61P25/20 ,  C07D401/04 ,  C07D413/14

Abstract: The present invention relates to a method for preparing 3-[(4S)-8-bromo-1-methyl-6-(pyridin-2-yl)-4H-imidazo[1,2-a] [1,4]benzodiazepin-4-yl]-propionic acid methyl ester starting from 3-[(3S)-7-bromo-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-[1,4]-benzodiazepin-3-yl] propionic acid methyl ester, and novel compounds useful as intermediates in said method, i.e., (3S)-3-[7-bromo-2-(2,2-dimethoxypropylamino)-5-pyridin-2-yl-3H-benzo[e] [1,4]diazepin-3-yl]propionic acid methyl ester.

公开(公告)号：US11236064B2

公开(公告)日：2022-02-01

申请号：US16634448

申请日：2018-07-27

Applicant: Moehs Iberica S.L.

Inventor： Carles Sánchez Casals ,  Alicia Dobarro Rodríguez

IPC: C07D401/04 ,  C07D213/50 ,  C07D487/04

Abstract: The present disclosure relates to a method for preparing 3-[(3S)-7-bromo-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-[1,4]-benzodiazepin-3-yl] propionic acid methyl ester from (2-amino-5-bromo-phenyl)-pyridin-2-yl-methanone. Also disclosed are compounds useful as intermediates in the method, methyl (4S)-4-amino-5-[4-bromo-2-(pyridin-2-carbonyl)anilino]-5-oxo-pentanoate hydrobromide salt and methyl (4S)-4-(benzyloxycarbonylamino)-5-[4-bromo-2-(pyridin-2-carbonyl)anilino]-5-oxo-pentanoate.

公开(公告)号：US20210139452A1

公开(公告)日：2021-05-13

申请号：US16634448

申请日：2018-07-27

Applicant: Moehs Iberica S.L.

Inventor： Carles Sánchez Casals ,  Alicia Dobarro Rodríguez

IPC: C07D401/04 ,  C07D487/04 ,  C07D213/50

Abstract: The present disclosure relates to a method for preparing 3-[(3S)-7-bromo-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-[1,4]-benzodiazepin-3-yl] propionic acid methyl ester from (2-amino-5-bromo-phenyl)-pyridin-2-yl-methanone. Also disclosed are compounds useful as intermediates in the method, methyl (4S)-4-amino-5-[4-bromo-2-(pyridin-2-carbonyl)anilino]-5-oxo-pentanoate hydrobromide salt and methyl (4S)-4-(benzyloxycarbonylamino)-5-[4-bromo-2-(pyridin-2-carbonyl)anilino]-5-oxo-pentanoate.