Systems and method are provided for canceling unwanted transmitter-to-receiver leakage in a coherent wireless system using a feedforward waveform that overcomes the limitations of purely analog or purely digital cancelation systems and methods. Systems and methods in accordance with embodiments of the present disclosure generate a software-defined waveform that, when fed forward into the receiver, effectively cancels the leakage. Embodiments of the present disclosure can use a defined cancelation waveform (e.g., a software-defined cancelation waveform) that can cancel multiple leakage paths at the same time.