Systems and techniques for generating and/or employing a computed tomography (CT) medical imaging stroke model are presented. In one example, a system employs a convolutional neural network to generate learned medical imaging stroke data regarding a brain anatomical region based on CT data associated with the brain anatomical region and diffusion-weighted imaging (DWI) data associated with one or more segmentation masks for the brain anatomical region. The system also detects presence or absence of a medical stroke condition in a CT image based on the learned medical imaging stroke data.