Invention Grant
![Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol](/docs/US/2022-05-17/US11332478B2/abs.jpg.600x600.jpg)
- Patent Title: Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol
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Application No.: US16828141Application Date: 2020-03-24
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Publication No.: US11332478B2Publication Date: 2022-05-17
- Inventor: Carla De Faveri , Florian Anton Martin Huber
- Applicant: H. Lundbeck A/S
- Applicant Address: DK Valby
- Assignee: H. Lundbeck A/S
- Current Assignee: H. Lundbeck A/S
- Current Assignee Address: DK Valby
- Agency: Wolf, Greenfield & Sacks, P.C.
- Priority: DKPA201500181 20150324
- Main IPC: C07D498/04
- IPC: C07D498/04 ; C07D491/113 ; C07D211/78 ; C07C269/04 ; C07C227/22 ; C07C227/18 ; C07C249/02 ; C07C271/22 ; C07C229/08
![Manufacture of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol](/abs-image/US/2022/05/17/US11332478B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to a process for synthesis of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol abbreviated THIP, having the INN name gaboxadol, starting from pyrrolidin-2-one. The process comprises a new direct process to obtain the intermediate dimethyl 5-hydroxy-3,6-dihydropyridine-1,4(2H)-dicarboxylate or the intermediate diethyl 5-hydroxy-3,6-dihydropyridine-1,4(2H)-dicarboxylate.
Public/Granted literature
- US20200223865A1 MANUFACTURE OF 4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL Public/Granted day:2020-07-16
Information query
