Invention Grant
- Patent Title: Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
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Application No.: US15261457Application Date: 2016-09-09
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Publication No.: US11332791B2Publication Date: 2022-05-17
- Inventor: John Allen Tynan , Grant Hogg
- Applicant: SEQUENOM, INC.
- Applicant Address: US CA San Diego
- Assignee: SEQUENOM, INC.
- Current Assignee: SEQUENOM, INC.
- Current Assignee Address: US CA San Diego
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12P19/34 ; C12Q1/6883 ; C12Q1/6886 ; C12Q1/6881
Abstract:
Provided are compositions and processes that utilize genomic regions that are differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are particularly useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuploidies.
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